A Virus Causes Cancer by Inducing Massive Chromosomal Instability through Cell Fusion

@article{Duelli2007AVC,
  title={A Virus Causes Cancer by Inducing Massive Chromosomal Instability through Cell Fusion},
  author={Dominik M. Duelli and Hesed M. Padilla-Nash and David J. Berman and Kathleen M Murphy and Thomas Ried and Yuri A. Lazebnik},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={431-437}
}
Chromosomal instability (CIN) underlies malignant properties of many solid cancers and their ability to escape therapy, and it might itself cause cancer [1, 2]. CIN is sustained by deficiencies in proteins, such as the tumor suppressor p53 [3-5], that police genome integrity, but the primary cause of CIN in sporadic cancers remains uncertain [6, 7]. The primary suspects are mutations that deregulate telomere maintenance, or mitosis, yet such mutations have not been identified in the majority of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…