A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5′UTRs

@inproceedings{Grey2010AVM,
  title={A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5′UTRs},
  author={Finn Grey and Rebecca S Tirabassi and Heather Meyers and Guanming Wu and Shannon K. McWeeney and Lauren M Hook and Jay A. Nelson},
  booktitle={PLoS pathogens},
  year={2010}
}
Global gene expression data combined with bioinformatic analysis provides strong evidence that mammalian miRNAs mediate repression of gene expression primarily through binding sites within the 3' untranslated region (UTR). Using RNA induced silencing complex immunoprecipitation (RISC-IP) techniques we have identified multiple cellular targets for a human cytomegalovirus (HCMV) miRNA, miR-US25-1. Strikingly, this miRNA binds target sites primarily within 5'UTRs, mediating significant reduction… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 44 references

Cyclin E2, the cycle continues.

The international journal of biochemistry & cell biology • 2002
View 4 Excerpts
Highly Influenced

Argonaute HITS-CLIP decodes microRNA-mRNA interaction

SW Chi, JB Zang, A Mele, RB Darnell
maps. Nature • 2009

The proteasomal system.

Molecular aspects of medicine • 2009
View 3 Excerpts

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