A Variety of Dicer Substrates in Human and C. elegans

  title={A Variety of Dicer Substrates in Human and C. elegans},
  author={Agnieszka Rybak-Wolf and Marvin Jens and Yasuhiro Murakawa and Margareta Herzog and Markus Landthaler and Nikolaus Rajewsky},
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer-binding sites. We find known and hundreds of additional miRNAs with high sensitivity and specificity. We also report structural RNAs, promoter RNAs, and mitochondrial transcripts as Dicer targets. Interestingly… CONTINUE READING
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