A Valuable Option for the Treatment of Respiratory Diseases: Review on the Clinical Evidence of the Ivy Leaves Dry Extract EA 575®.

@article{Lang2015AVO,
  title={A Valuable Option for the Treatment of Respiratory Diseases: Review on the Clinical Evidence of the Ivy Leaves Dry Extract EA 575{\textregistered}.},
  author={C. Lang and Patricia R{\"o}ttger-L{\"u}er and C. Staiger},
  journal={Planta medica},
  year={2015},
  volume={81 12-13},
  pages={
          968-74
        }
}
Preparations from ivy leaves (Hederae helicis folium, Hedera helix) dry extracts are well established in the treatment of different respiratory diseases. [...] Key Result Overall, 18 publications covering clinical trials and non-interventional studies of, in total, 65 383 patients suffering from acute as well as chronic respiratory diseases were included.Expand
Efficacy of two dosing schemes of a liquid containing ivy leaves dry extract EA 575 versus placebo in the treatment of acute bronchitis in adults
TLDR
A new dosing scheme was shown to be noninferior to the currently used scheme while maintaining the safety and tolerability of the well-established cough liquid containing EA 575. Expand
Ivy leaf (Hedera helix) for acute upper respiratory tract infections: an updated systematic review
TLDR
All studies concluded that ivy leaf extract is an effective and safe option for the treatment of cough due to URTIs and bronchitis and effects are minimal at best and of uncertain clinical importance. Expand
The effects of Hedera helix on viral respiratory infections in humans: A rapid review
TLDR
There is insufficient evidence to recommend the use of this supplement in the treatment or prevention of COVID-19, however, the current evidence justifies further research to better understand its applicability in coronavirus infections. Expand
The clinical efficacy of AG NPP709 (Synatura®) in patients with chronic bronchitis type stable chronic obstructive pulmonary disease.
TLDR
AG NPP709 improved the quality of life, as represented by the CAT score, in patients with chronic bronchitis type COPD, and significantly reduced fibrinogen levels. Expand
Plant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care.
TLDR
A broad spectrum of various commercial products currently available on the market and their well-documented clinical efficacy suggests that plants are prospective sources for the identification of new types of antimicrobial agents in future. Expand
Inhaled non-steroidal polyphenolic alternatives for anti-inflammatory combination therapy
TLDR
Pioneering an inhalable non-steroidal polyphenolic dry powder combination comprising curcumin, quercetin and trans-resveratrol from the phenolic acid, flavonoid and stilbene classes respectively, for benign anti-inflammatory therapy (without the corticosteroid-linked side effects). Expand
Anti-inflammatory effects of ivy leaves dry extract: influence on transcriptional activity of NFκB
TLDR
EA 575® is able to inhibit NFκB transcriptional activity by partially inhibiting its translocation to the nucleus after stimulation with TNFα, and phosphorylation of IκBα is reduced while phosphorylated of RelA is enhanced after pre-incubation with EA 575®, leading to an enhanced stability of NFκ B:IκB α complex and reduced RelA translocation into the nucleus. Expand
Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
TLDR
Saponin 29 showed significant anti-inflammatory and liver-protective effects in LPS/D-GalN-induced fulminant hepatic failure mice, and hold promise as therapeutic agents for inflammatory diseases. Expand
An OTC approach to managing cough
TLDR
Self-limiting coughs, such as those relating to a common cold or other viral upper respiratory tract infection, usually improve within a few days with or without treatment. Expand
A comparative study on the influence of an ivy preparation and an ivy/thyme combination on the β2-adrenergic signal transduction
TLDR
It can be concluded that the thyme fluid extract fraction in the ivy/thyme combination may have in part a negative effect on the β2-adrenergic signal transduction. Expand
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References

SHOWING 1-10 OF 45 REFERENCES
Treatment of acute respiratory infections in Slovenian children with ivy leaf extract syrup.
TLDR
The treatment with ivy leaf extract is safe in children with acute inflammatory airway disease and the majority of physicians and patients estimated that the treatment was more effective than in previous episodes of the disease when they had not received this drug. Expand
Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. an other ivy leaves extract.
TLDR
The test product with ivy leaves soft extract proved to be non-inferior to the comparator ivY leaves extract in improving symptoms of acute bronchitis. Expand
Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients.
  • S. Fazio, J. Pouso, +4 authors M. Hecker
  • Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2009
TLDR
In this postmarketing study, it is to say that the dried ivy leaf extract is effective and well tolerated in patients with bronchitis. Expand
Efeu – eine traditionelle Heilpflanze in der modernen Phytotherapie
TLDR
Triterpene saponins are the main ingredients and pharmacologically the most important substances of ivy leaf extracts, which are used in the treatment of chronic inflammatory bronchial disease and acute infection of the respiratory tract accompanied by coughing. Expand
Efficacy of dry extract of ivy leaves in children with bronchial asthma--a review of randomized controlled trials.
TLDR
The trials included in this review indicate that ivy leaf extract preparations have effects with respect to an improvement of respiratory functions of children with chronic bronchial asthma, but more far-reaching conclusions can hardly be drawn because of a meagre database. Expand
Tolerance and effect of an add-on treatment with a cough medicine containing ivy leaves dry extract on lung function in children with bronchial asthma.
TLDR
This proof-of-concept study indicates that children with mild uncontrolled asthma despite regular inhaled corticosteroid therapy might benefit from an additional therapy with ivy leaves dry extract, however, further studies are needed. Expand
Behandlung chronischer Bronchitis mit einem Spezialextrakt aus Efeublättern – multizentrische Anwendungsbeobachtung mit 1350 Patienten
TLDR
Considering the favorable changes in all investigated clinical symptoms as well as the excellent tolerability in children and adults, the ivy leaf extract preparation Prospan acute Effervescent Cough Tablets can be considered as a therapeutic option in alleviating the symptoms of chronic bronchitis. Expand
Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospan® Cough Tablets) in the treatment of colds accompanied by coughing.
TLDR
The results of this PMSS reflect the good to very good tolerability of the tablets in the global assessment by both, the practitioner and by the patient, and are one of the reasons for the high acceptance and compliance. Expand
In vitro antispasmodic compounds of the dry extract obtained from Hedera helix.
TLDR
The results indicate that the summed PEvalue of the compounds mentioned is an acceptable agreement with the PE value of the whole extract determined biologically. Expand
A systematic study on the influence of the main ingredients of an ivy leaves dry extract on the β2-adrenergic responsiveness of human airway smooth muscle cells.
TLDR
This systematic study focusing on the influence of the ingredients of an ivy leaves dry extract on HASM cells identified β-hederin as further component presumably responsible for the β2-mimetic effects. Expand
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