A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2

@article{CbeSuarez2006AVS,
  title={A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2},
  author={S. C{\'e}be Suarez and Michel Pieren and Luca Cariolato and S. Arn and Udo Hoffmann and Augustyn Bogucki and Corinne Manlius and Jeanette Marjorie Wood and Kurt Ballmer-Hofer},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={2067-2077}
}
Abstract.The development of functional blood and lymphatic vessels requires spatio-temporal coordination of the production and release of growth factors such as vascular endothelial growth factors (VEGFs). VEGF family proteins are produced in multiple isoforms with distinct biological properties and bind to three types of VEGF receptors. A VEGF-A splice variant, VEGF-A165b, has recently been isolated from kidney epithelial cells. This variant is identical to VEGF-A165 except for the last six… 

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