A Unified Nomenclature System for the Nuclear Receptor Superfamily

  title={A Unified Nomenclature System for the Nuclear Receptor Superfamily},
  author={Johan Auwerx and Etienne Emile Baulieu and Miguel Beato and Michael Becker-Andr{\'e} and Peter H. Burbach and Giovanna Camerino and Pierre Chambon and Austin John Cooney and Anne S. Dejean and Christine Dreyer and Ronald M. Evans and Frank Gannon and Vincent Gigu{\`e}re and Hinrich Gronemeyer and Jan-{\AA}ke Gustafsson and Vincent Laudet and Mitchell A. Lazar and David J. Mangelsdorf and Jeffrey Millbrandt and Edwin Milgrom and David D. Moore and Bert W. O’Malley and Maura Parker and Kathryn E R Parker and T. Perimann and Magnus Pfahl and Michael G. Rosenfeld and Herbert H. Samuels and Günther Schütz and Frances M. Sladek and Hendrik G. Stunnenberg and Michael Spedding and Carl S. Thummel and Ming-Jer Tsai and Kazuhiko Umesono and B. Vennstrom and Walter Wahli and C. Weinberg and Timothy M. Willson and K. R. Yamamoto},
unusual receptors that contain only one of the two conserved domains (C or E) were grouped into a separate subfamily (subfamily 0) irrespective of their evolutionary Nuclear hormone receptors (NRs) are important tran-origin. Within subfamilies, groups of receptors are de-scriptional regulators involved in widely diverse physio-fined as the most internal branches with bootstrap val-logical functions such as control of embryonic develop-ues above 90%. In this nomenclature system, the num-ment… Expand
Nuclear receptors are markers of animal genome evolution
Nuclear receptors are a very good model to investigate the dating and functional role of gene duplication, since they are dispersed in the genome, allow robust phylogenetic reconstruction, and are functionnaly well characterized, with different adaptations for different paralogs. Expand
Origins and evolutionary diversification of the nuclear receptor superfamily
  • G. Owen, A. Zelent
  • Medicine, Biology
  • Cellular and Molecular Life Sciences CMLS
  • 2000
The conservation in structure and function of distinct receptors across different species is reviewed and conclusions as to the evolution of this gene superfamily are drawn. Expand
NUREBASE: database of nuclear hormone receptors
NUREBASE, a database containing protein and DNA sequences, reviewed protein alignments and phylogenies, taxonomy and annotations for all nuclear receptors, is developed. Expand
Insect nuclear receptors.
A renewed focus on functional analysis of the isoforms of insect NRs is needed to understand the diverse roles of these transcription factors in embryogenesis, metamorphosis, reproduction, and homeostasis. Expand
Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.
Notably, differential gene loss played an important role in the evolution of different nuclear receptor sets in bilaterian lineages and was also shaped by periods of gene duplication in vertebrates, as well as a lineage-specific duplication burst in nematodes. Expand
Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors)
Detailed phylogenetic analysis using maximum likelihood methods to the entire complement of genes in the vertebrate NR superfamily shows that human and zebrafish PXRs show similar activation by steroid hormones and early bile salts, properties not shared by sea lamprey, mouse, or human VDRs, or by Xenopus laevis PxRs. Expand
Nuclear hormone receptor signaling in amphioxus
This study takes advantage of the unique features of the genome of the invertebrate amphioxus, which is characterized by a vertebrate-like gene content without having undergone massive duplications, to assess the NR signaling complement (NRs and NR coregulators) of the ancestral chordate. Expand
Explosive Lineage-Specific Expansion of the Orphan Nuclear Receptor HNF4 in Nematodes
It is shown that the supplementary nuclear receptors (supnrs) originated from an explosive burst of duplications of a unique orphan receptor, HNF4, and a model of lineage-specific duplications from a chromosome on which duplication and substitution rates are highly increased is proposed. Expand
Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome.
The exon structure of the ligand-binding domain suggests that exon shuffling has played a role in the evolution of this family of nuclear receptors, and an invariant splice junction in all members of the NR family except LXRbeta suggests a functional role for the intron. Expand
Nuclear receptors in nematode development: Natural experiments made by a phylum.
This review summarizes advances in research of nematode NRs and their developmental functions and represents the results of a large number of natural experiments with structural and functional potential of NRs for the evolution of the phylum. Expand


Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor.
  • V. Laudet
  • Biology, Medicine
  • Journal of molecular endocrinology
  • 1997
It is suggested that the ability to heterodimerize evolved once, just before the separation of subfamilies I and IV and that the first NR was able to bind to DNA as a homodimer, corresponding to the advent of vertebrates. Expand
The P450 gene superfamily: recommended nomenclature.
A nomenclature for the P450 gene superfamily is proposed based on evolution. Recommendations include Roman numerals for distinct gene families, capital letters for subfamilies, and Arabic numeralsExpand
The nuclear receptor superfamily: The second decade
This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli. Expand
The appropriate text citation for this letter in future publications will be: (Nuclear Receptors Nomenclature Committee
  • 1999
Orphan nuclear receptors--the first eight years.