A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

Abstract

Efficient repair of UV-induced DNA damage requires the precise coordination of nucleotide excision repair (NER) with numerous other biological processes. To map this crosstalk, we generated a differential genetic interaction map centered on quantitative growth measurements of >45,000 double mutants before and after different doses of UV radiation… (More)
DOI: 10.1016/j.celrep.2013.11.035

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@article{Srivas2013AUG, title={A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.}, author={Rohith Kannappan Srivas and Thomas Costelloe and Anne-Ruxandra Carvunis and Sovan Sarkar and Erik Malta and Su Ming Sun and Marijke Pool and Katherine Licon and Tibor van Welsem and Fred van Leeuwen and Peter J McHugh and Haico van Attikum and Trey Ideker}, journal={Cell reports}, year={2013}, volume={5 6}, pages={1714-24} }