A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats.

@article{He2012AUM,
  title={A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats.},
  author={Bosai He and Qing Li and Ying Jia and Longshan Zhao and Feng Xiao and Chunxiao Lv and Huarong Xu and Xiaohui Chen and Kaishun Bi},
  journal={Journal of mass spectrometry : JMS},
  year={2012},
  volume={47 10},
  pages={1333-40}
}
Suan-Zao-Ren (SZR) decoction, consisting of Ziziphi Spinosae Semen, Poria, Chuanxiong Rhizoma, Anemarrhenae Rhizoma and Glycyrrhizae Radix Et Rhizoma, is a Traditional Chinese Medicine prescription, clinically used for the treatment of insomnia. The objective of this study was to develop a sensitive and reliable UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid, the main active ingredients in SZR decoction, and to compare the pharmacokinetics of these… CONTINUE READING
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