A U-shaped association between consumption of marine n-3 fatty acids and development of atrial fibrillation/atrial flutter-a Danish cohort study.

@article{Rix2014AUA,
  title={A U-shaped association between consumption of marine n-3 fatty acids and development of atrial fibrillation/atrial flutter-a Danish cohort study.},
  author={Thomas Andersen Rix and Albert Marni Joensen and Sam Riahi and S{\o}ren Lundbye-Christensen and Anne Tj{\o}nneland and Erik Berg Schmidt and Kim Overvad},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  year={2014},
  volume={16 11},
  pages={
          1554-61
        }
}
  • T. RixA. M. Joensen K. Overvad
  • Published 26 February 2014
  • Medicine
  • Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
AIMS Previous studies have suggested a lower risk of atrial fibrillation (AF) with higher intakes of fish and marine n-3 polyunsaturated fatty acids (PUFAs), but the results have been inconsistent. The aim was to investigate the association between consumption of marine n-3 PUFA and development of AF. METHODS AND RESULTS A total of 57 053 Danish participants 50-64 years of age were enrolled in the Diet, Cancer, and Health Cohort Study between 1993 and 1997. Dietary intake of fish and marine n… 
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Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies.

Dietary Fish and Long-Chain n-3 Polyunsaturated Fatty Acids Intake and Risk of Atrial Fibrillation: A Meta-Analysis

A meta-analysis of prospective studies suggests that neither long-term intake of fish, nor of n-3 PUFAs were significantly associated with lower risk of AF.

Effect of Dietary Intake of Saturated Fatty Acids on the Development of Atrial Fibrillation and the Effect of Replacement of Saturated With Monounsaturated and Polyunsaturated Fatty Acids.

Dietary Fat Intake Is Differentially Associated with Risk of Paroxysmal Compared with Sustained Atrial Fibrillation in Women 1 – 3

Dietary fat was not associated with risk of incident AF in women without established CVD or AF and high SFA and low MUFA intakes were associated with greater risk of persistent or chronic, but not paroxysmal, AF.

Dietary Fat Intake Is Differentially Associated with Risk of Paroxysmal Compared with Sustained Atrial Fibrillation in Women.

D Dietary fat was not associated with risk of incident AF in women without established CVD or AF, and high SFA and low MUFA intakes were associated with greater risk of persistent or chronic, but not paroxysmal, AF.

Long-chain n-3 and n-6 polyunsaturated fatty acids and risk of atrial fibrillation: Results from a Danish cohort study

No associations between intake of n-3 or n-6 long chain polyunsaturated fatty acids and atrial fibrillation were found, neither when analyzed separately as primary exposures nor when interaction between n-1 and n-2 long chainpolyunsaturated acids was explored.

Omega-3 fatty acids in adipose tissue and risk of atrial fibrillation.

A monotonous inverse association was found for the content of EPA in adipose tissue and risk of AF in both men and women and thecontent of DHA was inversely associated with the risk of atrial fibrillation in women, whereas no clear association was finding for men.

Do omega-3 fatty acids increase risk of atrial fibrillation?

Clinicians should inform patients that marine omega-3 fatty acid supplement may increase AF risk, and this should be taking into account when discussing pros and cons of taking supplements with marine omega -3 fatty acids.

The coincidence of increased risk of atrial fibrillation in randomized control trials of omega-3 fatty acids: a meta-analysis

There are adequate large-scale randomized controlled trials for a meta-analysis to summarize the existing evidence on the overall effect of omega-3 fatty acids on the development of atrial fibrillation, and two investigators performed a systematic literature search in electronic databases for randomized controlled Trials that reported new-onset incident/recurrent AF.

Mediterranean Diet: A Tool to Break the Relationship of Atrial Fibrillation with the Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease

Current evidence on the association between AF, MetS and NAFLD, the antioxidant role of Mediterranean Diet and its components for the prevention of AF and the effects of Mediterranean diet on MetS components andNAFLD are summarized.

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