A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities

@article{Zang2013ATypePF,
  title={A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities},
  author={Xin-yu Zang and Ming-Ying Shang and Feng Xu and Jing Liang and Xuan Wang and Masayuki Mikage and Shao-Qing Cai},
  journal={Molecules},
  year={2013},
  volume={18},
  pages={5172 - 5189}
}
Phytochemical investigation of the n-BuOH-soluble fraction of the EtOH extract of the herbaceous stems of Ephedra sinica, which is known as Ephedrae Herba in Traditional Chinese Medicine, led to the isolation and identification of 12 A-type proanthocyanidins, containing five dimers, two trimers and five tetramers [i.e., (+)-epigallocatechin-(2α→O→7,4α→8)-(-)-catechin, named ephedrannin D1, a dimer; epigallocatechin-(2α→O→7,4α→8)-epigallocatechin-(4α→8)-catechin (ephedrannin Tr1), a trimer; and… 
Characterization of Proanthocyanidin Oligomers of Ephedra sinica
TLDR
Algae-catalyzed degradation in the presence of mercaptoethanol or phloroglucinol led to the isolation of 18 fragments, the structures of which were elucidated from their experimental and TDDFT-calculated ECD spectra.
Dioic acid glycosides, tannins and methylated ellagic acid glycosides from Morella salicifolia bark
Abstract The bark of Morella salicifolia ( Hochst . ex A. Rich. ) Verdc . & Polhill (Myricaceae) is a common herbal drug and especially utilized by the Maasai community of northeastern Tanzania. It
Structure Elucidation of Procyanidins Isolated from Rhododendron formosanum and Their Anti-Oxidative and Anti-Bacterial Activities
TLDR
The pleiotropic effects of procyanidins isolated from the leaves of R. formosanum can be a source of promising compounds for the development of future pharmacological applications and the activities are enhanced as the amount of OH groups in procyAnidins increased.
Phytochemistry and pharmacology of genus Ephedra.
TLDR
The in vitro and in vivo pharmacological studies on the crude extracts, fractions and few isolated compounds of Ephedra species showed anti-inflammatory, anticancer, antibacterial, antioxidant, hepatoprotective, anti-obesity, antiviral, and diuretic activities.
A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties
TLDR
The present review represents a key compilation of all the relevant information for the Ephedra genus, in particular the American species, the species distribution, their ecological interactions, its ethnobotany, its phytochemistry and their pharmacological activities and toxicities, in order to promote clear directions for future research.
Antifungal and cytotoxicity activities and new proanthocyanidins isolated from the barks of Inga laurina (Sw.) Willd
Abstract The Inga genus comprises approximately 300 species that can be found from Mexico to northern Argentina. In folk medicine, Inga species are used to treat various diseases. The species Inga
Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations
TLDR
The experimental results suggest that the biological activity of G. collinum is related to its polyphenol contents, and the potent antidiabetic activity of the 50% aqueous-ethanolic extract from G.collinum shows promise for its future application in medicine.
A review of the phytochemistry and pharmacological activities of Ephedra herb.
TLDR
This study systematically reviews its progress of phytochemistry, traditional and modern pharmacology based on research data that have been reported, aiming at providing useful insight for commercial exploitation, further study and precision medication of Ephedra herb in future.
N-Substituted acetamide glycosides from the stems of Ephedra sinica
Abstract Five new N -mono-/bis-substituted acetamide glycosides, N -{4- O -[3- O -(4- O -α- l -rhamnopyranosyl-β- d -glucopyranosyl)-α- l -rhamnopyranosyl]-phenethyl}-acetamide ( 1 ), N -methyl- N
PHYTOCHEMICALANALYSIS OF THE LEAF, STEM AND SEED EXTRACTS OF CAJANUS CAJAN L(DICOTYLEDONEAE: FABACEAE)
TLDR
Investigation of the qualitative and quantitative phytochemical analysis of leaf seed and stem extracts of Cajanus cajan L found presence of saponins, tannins, alkaloids flavonoids, anthraquinones and reducing sugars contributes to its medicinal properties making it widely used in traditional medicines.
...
1
2
3
4
...

References

SHOWING 1-10 OF 46 REFERENCES
Tannins and Related Compounds.XCI. : Isolation and Characterization of Proanthocyanidins with an Intramolecularly Doubly-Linked Unit from the Fern, Dicranopteris pedata HOUTT.
A chemical examination of the polyphenolic constituents of the fern, Dicranopteris pedata HOUTT., has led to the isolation of eight new proanthocyanidins possessing a doubly-linked (A-type) unit,
Dimeric proanthocyanidins from the roots of Ephedra sinica.
TLDR
Two new dimeric proanthocyanidins were isolated from the roots of Ephedra sinica Stapf and the structures of the new compounds were deduced to be 5,7,4'-trihydroxyflavan and EPI-afzelechin.
A-type Proanthocyanidins from stem-bark of Pavetta owariensis
Abstract In a chemical investigation on the stem-bark of Pavetta owariensis , a new proanthocyanidin A-type, ent -epicatechin (4α→8,2α→ O →7)- ent -catechin designated as pavetannin A1, was isolated
Ephedrannin A and B from roots of Ephedra sinica inhibit lipopolysaccharide-induced inflammatory mediators by suppressing nuclear factor-κB activation in RAW 264.7 macrophages.
TLDR
This is the first report describing effective anti-inflammatory activity for ephedrannin A and B isolated from Ephedra roots and may be a good candidate for delaying the progression of human inflammatory diseases and warrants further studies.
Antimicrobial properties of Quercus ilex L. proanthocyanidin dimers and simple phenolics: evaluation of their synergistic activity with conventional antimicrobials and prediction of their pharmacokinetic profile.
TLDR
Results showed that proanthocyanidins 3 and 4 when combined with bifonazole and ketoconazole increase the activity of both of these conventional fungicides.
Biological evaluation of proanthocyanidin dimers and related polyphenols.
TLDR
In general, more pronounced activities were seen with epicatechin-containing dimers for anti- HSV, anti-HIV, and radical-scavenging effects, while the presence of ortho-trihydroxyl groups in the B-ring was important in compounds exhibiting anti-HSV andradical-scvenging effects and complement classical pathway inhibition.
Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects.
TLDR
Isolated polyphenols showed inhibitory effects on nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation in microsomes and on the autoxidation of linoleic acid, attributed to the radical-scavenging activity in thePeroxidation chain reactions.
New observations on the secondary chemistry of world Ephedra (Ephedraceae).
TLDR
For several millennia, stem extracts of Ephedra have been used as folk medicines in both the Old and New World, and together with Asian species they contain other nitrogen-containing secondary metabolites with known neuropharmacological activity.
Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs 7630) and pharmacological screening in CNS models.
  • K. Schötz, M. Nöldner
  • Chemistry, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2007
TLDR
In vivo studies investigating motility, body weight gain, body temperature, motoric coordination, anticonvulsant effects and central analgesic activities, showed no or only moderate pharmacological effects, indicating, that proanthocyanidin oligomers have no intrinsic behavioural activities.
Antiviral and antiphlogistic activities of Hamamelis virginiana bark.
TLDR
The UF-concentrate was found to exhibit significant antiviral activity against Herpes simplex virus type 1 (HSV-1) and exhibited strong antiphlogistic effects in the croton oil ear edema test in the mouse.
...
1
2
3
4
5
...