A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer

@article{Armitage1957ATT,
  title={A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer},
  author={Paul Armitage and Richard Doll},
  journal={British Journal of Cancer},
  year={1957},
  volume={11},
  pages={161 - 169}
}
OVER a wide range of ages, the mortality from various types of human cancer rises approximately in proportion to a high power of the age, and Muller (1951), Nordling (1953) and Stocks (1953) have independently suggested that this could be accounted for if the development of cancer were the end-result of a series of discrete cellular changes-such, for example, as would be produced by somatic mutations. In a previous paper we tested the hypothesis by examining separately the relationship between… CONTINUE READING
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