A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss

@article{Phelps2009ATM,
  title={A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss},
  author={Reid A. Phelps and Stephanie Chidester and Somaye Dehghanizadeh and Jason Phelps and Imelda T Sandoval and Kunal Rai and Talmage Broadbent and Sharmistha Sarkar and Randall W. Burt and David A Jones},
  journal={Cell},
  year={2009},
  volume={137},
  pages={623-634}
}
Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and human cells, we show that homozygous loss of APC causes failed intestinal cell differentiation but that this occurs in the absence of nuclear beta-catenin and increased intestinal cell proliferation. Therefore, loss of APC is insufficient for causing beta-catenin nuclear localization. APC mutation-induced intestinal… CONTINUE READING

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