A Turn-Key Approach for Large-Scale Identification of Complex Posttranslational Modifications

@inproceedings{Wang2014ATA,
  title={A Turn-Key Approach for Large-Scale
Identification
of Complex Posttranslational Modifications},
  author={Jian Wang and Veronica G. Anania and Jeff Knott and John V. Rush and Jennie R Lill and Philip E. Bourne and Nuno Bandeira},
  booktitle={Journal of proteome research},
  year={2014}
}
The conjugation of complex post-translational modifications (PTMs) such as glycosylation and Small Ubiquitin-like Modification (SUMOylation) to a substrate protein can substantially change the resulting peptide fragmentation pattern compared to its unmodified counterpart, making current database search methods inappropriate for the identification of tandem… CONTINUE READING