A Trypanosoma brucei brucei-derived factor that triggers CD8+ lymphocytes to interferon-gamma secretion: purification, characterization and protective effects in vivo by treatment with a monoclonal antibody against the factor.

@article{Bakhiet1993ATB,
  title={A Trypanosoma brucei brucei-derived factor that triggers CD8+ lymphocytes to interferon-gamma secretion: purification, characterization and protective effects in vivo by treatment with a monoclonal antibody against the factor.},
  author={Moiz Bakhiet and Tomas Olsson and Charlotta Edlund and Bo H{\"o}jeberg and Kerstin Holmberg and Johnny Lorentzen and Krister Kristensson},
  journal={Scandinavian journal of immunology},
  year={1993},
  volume={37 2},
  pages={165-78}
}
A protein factor that stimulates CD8+ lymphocytes to produce and secrete IFN-gamma has been purified from Trypanosoma brucei brucei (T.b. brucei). This was accomplished by raising monoclonal antibodies (MoAbs) against a fraction of T.b. brucei obtained by gel filtration, which contained high levels of material inducing rat mononuclear cells (MNC) to IFN-gamma production. MoAbs from four hybridomas strongly inhibited trypanosome-induced IFN-gamma production. One of them (MO1) was used for… CONTINUE READING