A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1.

@article{Nisole2004ATA,
  title={A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1.},
  author={S{\'e}bastien Nisole and Clare Lynch and Jonathan P Stoye and Melvyn W. Yap},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 36},
  pages={13324-8}
}
Lv1 restriction of HIV-1 in the cells of Old World monkeys is associated with the expression of the Trim5 gene. Uniquely, in owl monkey kidney cells, HIV-1 restriction is dependent on the ability of incoming viral capsid protein to bind cyclophilin A (CypA). Cloning of the owl monkey Trim5 gene now reveals the presence of an inserted CypA pseudogene within intron 7 of the Trim5 gene. This insertion results in the formation of a chimeric Trim5-CypA transcript. Transfer of a cDNA corresponding to… CONTINUE READING
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