A Transposon in Comt Generates mRNA Variants and Causes Widespread Expression and Behavioral Differences among Mice

@inproceedings{Li2010ATI,
  title={A Transposon in Comt Generates mRNA Variants and Causes Widespread Expression and Behavioral Differences among Mice},
  author={Zhengsheng Li and Megan K. Mulligan and Xusheng Wang and Michael F. Miles and Lu Lu and Robert W. Williams},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine. COMT activity influences cognitive and emotional states in humans and aggression and drug responses in mice. This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and behavioral traits. METHODOLOGY/PRINCIPAL FINDINGS We examined Comt expression in… CONTINUE READING

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