A Translation Initiation Element Specific to mRNAs with Very Short 5′UTR that Also Regulates Transcription

@article{Elfakess2008ATI,
  title={A Translation Initiation Element Specific to mRNAs with Very Short 5′UTR that Also Regulates Transcription},
  author={Rofa Elfakess and Rivka Dikstein},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={28 - 36}
}
Transcription is controlled by cis regulatory elements, which if localized downstream to the transcriptional start site (TSS), in the 5'UTR, could influence translation as well. However presently there is little evidence for such composite regulatory elements. We have identified by computational analysis an abundant element located downstream to the TSS up to position +30, which controls both transcription and translation. This element has an invariable ATG sequence, which serves as the… CONTINUE READING

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