A Transgenic Mouse Model with Cyclin Dl Overexpression Results in Cell Cycle , Epidermal Growth Factor Receptor , and p 53 Abnormalities 1

@inproceedings{Mueller2008ATM,
  title={A Transgenic Mouse Model with Cyclin Dl Overexpression Results in Cell Cycle , Epidermal Growth Factor Receptor , and p 53 Abnormalities 1},
  author={Annegret Mueller and Robert Odze and Timothy D. Jenkins and Ali Shahsesfaei and Hiroshi Nakagawa and Takuya liminolo and Anil K Rustgi},
  year={2008}
}
The cyclin DI oncogene is critical in the progression of the cell cycle through the (ì,phase. It is frequently overexpressed in squamous cell carcinomas originating from the head/neck and esophagus. Yet, the func tional consequences of aberrant cyclin 1)1 overexpression are not entirely understood apart from increased cell proliferation. To address this ques tion, we have developed a transgenic mouse model in which the EBV 1 l)-l 2 promoter targets cyclin DI to the stratified squamous… CONTINUE READING