A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

@article{Masuzaki2001ATM,
  title={A Transgenic Model of Visceral Obesity and the Metabolic Syndrome},
  author={Hideaki Masuzaki and Josh Paterson and Hiroshi Shinyama and Nicholas M. Morton and John J. Mullins and Jonathan R Seckl and Jeffrey S. Flier},
  journal={Science},
  year={2001},
  volume={294},
  pages={2166 - 2170}
}
  • Hideaki Masuzaki, Josh Paterson, +4 authors Jeffrey S. Flier
  • Published 2001
  • Biology, Medicine
  • Science
  • The adverse metabolic consequences of obesity are best predicted by the quantity of visceral fat. Excess glucocorticoids produce visceral obesity and diabetes, but circulating glucocorticoid levels are normal in typical obesity. Glucocorticoids can be produced locally from inactive 11-keto forms through the enzyme 11β hydroxysteroid dehydrogenase type 1 (11β HSD-1). We created transgenic mice overexpressing 11β HSD-1 selectively in adipose tissue to an extent similar to that found in adipose… CONTINUE READING

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