A Transcription Factor Network Coordinates Attraction, Repulsion, and Adhesion Combinatorially to Control Motor Axon Pathway Selection

@article{Zarin2014ATF,
  title={A Transcription Factor Network Coordinates Attraction, Repulsion, and Adhesion Combinatorially to Control Motor Axon Pathway Selection},
  author={Aref Arzan Zarin and Jamshid Asadzadeh and Karsten Hokamp and Daniel M. A. McCartney and Long Yang and Greg J Bashaw and J Labrador},
  journal={Neuron},
  year={2014},
  volume={81},
  pages={1297-1311}
}
Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; however, how these factors impinge on surface molecules that control guidance decisions is poorly understood. Using mRNA profiling, we identified the complement of membrane molecules regulated by the homeobox TF Even-skipped (Eve), the major determinant of dorsal motor neuron (dMN) identity in Drosophila. Combinatorial loss- and gain-of-function genetic analyses of Eve target genes… CONTINUE READING
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