A Trail of Research from Lipoic Acid to-Keto Acid Dehydrogenase Complexes

  title={A Trail of Research from Lipoic Acid to-Keto Acid Dehydrogenase Complexes},
  author={Lester J. Reed},
In this article I shall retrace a trail of research that began with the isolation and characterization of a microbial growth factor and led to elucidation of the structure, function, and regulation of -keto acid dehydrogenase complexes. The high points of this trail are presented below. Isolation and Characterization of Lipoic Acid This trail of discovery started in the spring of 1949, about 6 months after I joined the faculty of the Department of Chemistry at the University of Texas. At that… CONTINUE READING


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