A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization

@article{MargetaMitrovic2000ATC,
  title={A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization},
  author={Marta Margeta-Mitrovic and Yuh Nung Jan and Lily Yeh Jan},
  journal={Neuron},
  year={2000},
  volume={27},
  pages={97-106}
}
Surface expression of GABA(B) receptors requires heterodimerization of GB1 and GB2 subunits, but little is known about mechanisms that ensure efficient heterodimer assembly. We found that expression of the GB1 subunit on the cell surface is prevented through a C-terminal retention motif RXR(R); this sequence is reminiscent of the ER retention/retrieval motif RKR identified in subunits of the ATP-sensitive K+ channel. Interaction of GB1 and GB2 through their C-terminal coiled-coil alpha helices… Expand
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  • 2020
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