A Toxicogenomic Approach for the Prediction of Murine Hepatocarcinogenesis Using Ensemble Feature Selection

@article{Eichner2013ATA,
  title={A Toxicogenomic Approach for the Prediction of Murine Hepatocarcinogenesis Using Ensemble Feature Selection},
  author={Johannes Eichner and Nadine Kossler and Clemens Wrzodek and A. Kalkuhl and Dorthe Bach Toft and N. Ostenfeldt and Virgile Richard and A. Zell},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
The current strategy for identifying the carcinogenicity of drugs involves the 2-year bioassay in male and female rats and mice. As this assay is cost-intensive and time-consuming there is a high interest in developing approaches for the screening and prioritization of drug candidates in preclinical safety evaluations. Predictive models based on toxicogenomics investigations after short-term exposure have shown their potential for assessing the carcinogenic risk. In this study, we investigated… Expand
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