A Topology-Based Score for Pathway Enrichment

@article{Ibrahim2012ATS,
  title={A Topology-Based Score for Pathway Enrichment},
  author={Maysson Al-Haj Ibrahim and Sabah Jassim and Michael Anthony Cawthorne and Kenneth Langlands},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2012},
  volume={19 5},
  pages={
          563-73
        }
}
Investigators require intuitive tools to rationalize complex datasets generated by transcriptional profiling experiments. Pathway analysis methods, in which differentially expressed genes are mapped to databases of reference pathways to facilitate assessment of relative enrichment, lead investigators more effectively to biologically testable hypotheses. However, once a set of differentially expressed genes is isolated, pathway analysis approaches tend to ignore rich gene expression information… CONTINUE READING
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