A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

@article{Ju2006ATI,
  title={A Topoisomerase II{\ss}-Mediated dsDNA Break Required for Regulated Transcription},
  author={Bong-gun Ju and Victoria V. Lunyak and Valentina Perissi and Ivan Garcia-Bassets and David W. Rose and Christopher K. Glass and Michael G. Rosenfeld},
  journal={Science},
  year={2006},
  volume={312},
  pages={1798 - 1802}
}
Multiple enzymatic activities are required for transcriptional initiation. The enzyme DNA topoisomerase II associates with gene promoter regions and can generate breaks in double-stranded DNA (dsDNA). Therefore, it is of interest to know whether this enzyme is critical for regulated gene activation. We report that the signal-dependent activation of gene transcription by nuclear receptors and other classes of DNA binding transcription factors, including activating protein 1, requires DNA… 
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