A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

  title={A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis},
  author={Stephen Boulton and Madoka Akimoto and Rajeevan Selvaratnam and Amir Bashiri and Giuseppe Melacini},
  booktitle={Scientific reports},
Allostery is an essential regulatory mechanism of biological function. Allosteric sites are also pharmacologically relevant as they are often targeted with higher selectivity than orthosteric sites. However, a comprehensive map of allosteric sites poses experimental challenges because allostery is driven not only by structural changes, but also by modulations in dynamics that typically remain elusive to classical structure determination methods. An avenue to overcome these challenges is… CONTINUE READING

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