A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift Signal

  title={A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift Signal},
  author={Ewan P Plant and Gabriela C. P{\'e}rez-Alvarado and Jonathan L. Jacobs and Bani Mukhopadhyay and Mirko Hennig and Jonathan D. Dinman},
  journal={PLoS Biology},
  pages={664 - 675}
A wide range of RNA viruses use programmed -1 ribosomal frameshifting for the production of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the SARS-CoV genome revealed that, similar to all coronaviruses, a programmed -1 ribosomal frameshift could be used by the virus to produce a fusion protein. Computational analyses of the frameshift signal predicted the presence of an mRNA pseudoknot containing three double-stranded RNA stem structures rather than two… CONTINUE READING


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Characterization of an efficient coronavirus ribosomal frameshifting signal: Requirement for an RNA pseudoknot

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