A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain

@article{Worsley1992ATS,
  title={A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain},
  author={Keith J. Worsley and Alan C. Evans and Sean Marrett and Peter Neelin},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={1992},
  volume={12},
  pages={900 - 918}
}
Many studies of brain function with positron emission tomography (PET) involve the interpretation of a subtracted PET image, usually the difference between two images under baseline and stimulation conditions. The purpose of these studies is to see which areas of the brain are activated by the stimulation condition. In many cognitive studies, the activation is so slight that the experiment must be repeated on several subjects and the subtracted images are averaged to improve the signal-to-noise… 
Detecting and estimating the regions of activation in CBF activation studies in human brain
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Normalizing Counts and Cerebral Blood Flow Intensity in Functional Imaging Studies of the Human Brain
TLDR
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