A Three-Dimensional Model of the Yeast Genome

  title={A Three-Dimensional Model of the Yeast Genome},
  author={Zhijun Duan and Mirela S Andronescu and Kevin Schutz and Sean Mcllwain and Yoo Jung Kim and Choli Lee and Jay Shendure and Stanley Fields and C. Anthony Blau and William Stafford Noble},
Layered on top of information conveyed by DNA sequence and chromatin are higher order structures that encompass portions of chromosomes, entire chromosomes, and even whole genomes. Interphase chromosomes are not positioned randomly within the nucleus, but instead adopt preferred conformations. Disparate DNA elements co-localize into functionally defined aggregates or ‘factories’ for transcription and DNA replication. In budding yeast, Drosophila and many other eukaryotes, chromosomes adopt a… CONTINUE READING
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