A Threading-Based Method for the Prediction of DNA-Binding Proteins with Application to the Human Genome

@inproceedings{Gao2009ATM,
  title={A Threading-Based Method for the Prediction of DNA-Binding Proteins with Application to the Human Genome},
  author={Mu Gao and Jeffrey Skolnick},
  booktitle={PLoS Computational Biology},
  year={2009}
}
Diverse mechanisms for DNA-protein recognition have been elucidated in numerous atomic complex structures from various protein families. These structural data provide an invaluable knowledge base not only for understanding DNA-protein interactions, but also for developing specialized methods that predict the DNA-binding function from protein structure. While such methods are useful, a major limitation is that they require an experimental structure of the target as input. To overcome this… CONTINUE READING