A Therapeutic Target for Hormone-independent Estrogen Receptor-positive Breast Cancers

@article{Biswas2001ATT,
  title={A Therapeutic Target for Hormone-independent Estrogen Receptor-positive Breast Cancers},
  author={Debajit K. Biswas and Adolfo Molina Cruz and Nicholas Pettit and George L. Mutter and Arthur B. Pardee},
  journal={Molecular Medicine},
  year={2001},
  volume={7},
  pages={59-67}
}
BackgroundThe action of the steroid hormone estradiol (E2) is mediated via interaction with a specific receptor (ER) that initiates a series of events downstream, leading to the modulation of hormone-responsive genes and cell proliferation. Antihormones also bind, but do not confer the active configuration to ER, thereby, blocking the transmission of E2-ER-initiated signals for cell proliferation. Although these compounds qualify for successful therapy of ER-positive [ER (+)] breast cancer… CONTINUE READING
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