A Theory of the Transition to Critical Period Plasticity: Inhibition Selectively Suppresses Spontaneous Activity

@article{Toyoizumi2013ATO,
  title={A Theory of the Transition to Critical Period Plasticity: Inhibition Selectively Suppresses Spontaneous Activity},
  author={Taro Toyoizumi and Hiroyuki Miyamoto and Yoko Yazaki-Sugiyama and Nafiseh Atapour and Takao K Hensch and Kenneth D. Miller},
  journal={Neuron},
  year={2013},
  volume={80},
  pages={51-63}
}
What causes critical periods (CPs) to open? For the best-studied case, ocular dominance plasticity in primary visual cortex in response to monocular deprivation (MD), the maturation of inhibition is necessary and sufficient. How does inhibition open the CP? We present a theory: the transition from pre-CP to CP plasticity arises because inhibition preferentially suppresses responses to spontaneous relative to visually driven input activity, switching learning cues from internal to external… CONTINUE READING
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