A Theory of Self-Nonself Discrimination

@article{Bretscher1970ATO,
  title={A Theory of Self-Nonself Discrimination},
  author={Peter A Bretscher and Melvin Cohn},
  journal={Science},
  year={1970},
  volume={169},
  pages={1042 - 1049}
}
1) Induction of humoral antibody formation involves the obligatory recognition of two determinants on an antigen, one by the receptor antibody of the antigen-sensitive cell and the other by carrier antibody (associative interaction). 2) Paralysis of antibody formation involves the obligatory recognition of only one determinant by the receptor antibody of the antigen-sensitive cell; that is, a nonimmunogenic molecule (a hapten) can paralyze antigen-sensitive cells. 3) There is competition… 

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Self‐Nonself Discrimination in the Immune System A Broken Idiotypic Mirror a

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...

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