A Theory of Self-Nonself Discrimination

@article{Bretscher1970ATO,
  title={A Theory of Self-Nonself Discrimination},
  author={Peter A Bretscher and Melvin Cohn},
  journal={Science},
  year={1970},
  volume={169},
  pages={1042 - 1049}
}
1) Induction of humoral antibody formation involves the obligatory recognition of two determinants on an antigen, one by the receptor antibody of the antigen-sensitive cell and the other by carrier antibody (associative interaction). 2) Paralysis of antibody formation involves the obligatory recognition of only one determinant by the receptor antibody of the antigen-sensitive cell; that is, a nonimmunogenic molecule (a hapten) can paralyze antigen-sensitive cells. 3) There is competition… Expand
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Immunogenicity of an antigen is dependent both on possession of antigenic determinants, including the haptenic portion(s) of the antigen, and binding groups, and the relationships of these ligands during processing on a cellular processing template to form an antibody RNA. Expand
The T-cell receptor mediating restrictive recognition of antigen
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Passive antibody and the immune response. Factors which determine enhancement and suppression.
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