A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand
@article{Wu2003ATA, title={A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand}, author={H. Wu and N. Zink and L. Carter and A. Mehta and R. Hernandez and M. Ticku and R. Lamb and C. France and A. Coop}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2003}, volume={305}, pages={675 - 679} }
γ-Hydroxybutyric acid (GHB) shows great promise as a treatment for sleeping disorders but is also increasingly abused. The exact mechanism of action of GHB is yet to be delineated, but it is known to interact with specific GHB binding sites or receptors, to act as a weak agonist at GABAB receptors, and that GHB undergoes metabolism to GABA. In drug discrimination studies, GABAB agonists, and to a lesser extent GABAA-positive modulators, substitute for GHB. To delineate the relative… CONTINUE READING
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References
SHOWING 1-10 OF 31 REFERENCES
Binding characteristics of γ-hydroxybutyric acid as a weak but selective GABAB receptor agonist
- Biology
- 1997
- 123
Relation of the [3H]γ-hydroxybutyric acid (ghb) binding site to the γ-aminobutyric acidb (gabab) receptor in rat brain
- Chemistry
- 1996
- 59
Central effects of 1,4-butanediol are mediated by GABAB receptors via its conversion into γ-hydroxybutyric acid
- Chemistry
- 2002
- 60
Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1988
- 47
gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1997
- 85
- PDF
The Role of GABAB Receptors in the Discriminative Stimulus Effects of γ-Hydroxybutyrate in Rats: Time Course and Antagonism Studies
- Chemistry, Medicine
- Journal of Pharmacology and Experimental Therapeutics
- 2003
- 72
- PDF
A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1990
- 147
γ-Hydroxybutyric acid binding sites: Evidence for coupling to a chloride anion channel
- Chemistry, Medicine
- Neuropharmacology
- 1987
- 46