A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand

@article{Wu2003ATA,
  title={A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand},
  author={H. Wu and N. Zink and L. Carter and A. Mehta and R. Hernandez and M. Ticku and R. Lamb and C. France and A. Coop},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={305},
  pages={675 - 679}
}
  • H. Wu, N. Zink, +6 authors A. Coop
  • Published 2003
  • Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • γ-Hydroxybutyric acid (GHB) shows great promise as a treatment for sleeping disorders but is also increasingly abused. The exact mechanism of action of GHB is yet to be delineated, but it is known to interact with specific GHB binding sites or receptors, to act as a weak agonist at GABAB receptors, and that GHB undergoes metabolism to GABA. In drug discrimination studies, GABAB agonists, and to a lesser extent GABAA-positive modulators, substitute for GHB. To delineate the relative… CONTINUE READING
    19 Citations
    Novel γ-Hydroxybutyric Acid (GHB) Analogs Share Some, but Not All, of the Behavioral Effects of GHB and GABAB Receptor Agonists
    • 43
    • PDF
    Novel Cyclic γ-Hydroxybutyrate (GHB) Analogs with High Affinity and Stereoselectivity of Binding to GHB Sites in Rat Brain
    • 31
    • PDF
    Characterization and Pharmacology of the GHB Receptor
    • M. Ticku, A. Mehta
    • Chemistry, Medicine
    • Annals of the New York Academy of Sciences
    • 2008
    • 4
    Gamma-hydrobutyric acid (GHB) and its chemical modifications: a review of the GHBergic system.
    • 21
    • Highly Influenced
    Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats
    • 17
    • Highly Influenced

    References

    SHOWING 1-10 OF 31 REFERENCES
    Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.
    • 47
    gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.
    • 85
    • PDF
    The Role of GABAB Receptors in the Discriminative Stimulus Effects of γ-Hydroxybutyrate in Rats: Time Course and Antagonism Studies
    • 72
    • PDF
    A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties.
    • 147