A Taste Receptor Required for the Caffeine Response In Vivo

  title={A Taste Receptor Required for the Caffeine Response In Vivo},
  author={Seok Jun Moon and Michael K{\"o}ttgen and Yuchen Jiao and Hong Xu and Craig T. Montell},
  journal={Current Biology},
Caffeine is a methylxanthine present in the coffee tree, tea plant, and other naturally occurring sources and is among the most commonly consumed drugs worldwide. Whereas the pharmacological action of caffeine has been studied extensively, relatively little is known concerning the molecular mechanism through which this substance is detected as a bitter compound. Unlike most tastants, which are detected through cell-surface G protein-coupled receptors, it has been proposed that caffeine and… CONTINUE READING
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