A Targeted Disruption in Connexin40 Leads to Distinct Atrioventricular Conduction Defects

@article{Bevilacqua2000ATD,
  title={A Targeted Disruption in Connexin40 Leads to Distinct Atrioventricular Conduction Defects},
  author={Laura M. Bevilacqua and Alexander M. Simon and Colin T. Maguire and Josef Gehrmann and Hiroko Wakimoto and David L. Paul and Charles I. Berul},
  journal={Journal of Interventional Cardiac Electrophysiology},
  year={2000},
  volume={4},
  pages={459-567}
}
Introduction: Gap junctions consist of connexin (Cx) proteins that enable electrical coupling of adjacent cells and propagation of action potentials. Cx40 is solely expressed in the atrium and His-Purkinje system. The purpose of this study was to evaluate atrioventricular (AV) conduction in mice with a homozygous deletion of Connexin40 (Cx40−/−). Methods: Surface ECGs, intracardiac electrophysi-ology (EP) studies, and ambulatory telemetry were performed in Cx40−/− mutant mice and wild-type (WT… CONTINUE READING

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