A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

@inproceedings{Sharlow2010ATH,
  title={A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity},
  author={Elizabeth R. Sharlow and Todd A Lyda and Heidi C. Dodson and Gabriela Mustata and Meredith Teilhet Morris and Stephanie S. Leimgruber and Kuo-Hsiung Lee and Yoshiki Kashiwada and David Close and John S Lazo and James C Morris},
  booktitle={PLoS neglected tropical diseases},
  year={2010}
}
BACKGROUND The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. Here we describe the identification and… CONTINUE READING