A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland

@inproceedings{Pakula2017ATO,
  title={A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland},
  author={Hubert Pakula and Dongxi Xiang and Zhe Li},
  booktitle={Cancers},
  year={2017}
}
Prostate cancer (PCa) is one of the most common cancers and among the leading causes of cancer deaths for men in industrialized countries. It has long been recognized that the prostate is an androgen-dependent organ and PCa is an androgen-dependent disease. Androgen action is mediated by the androgen receptor (AR). Androgen deprivation therapy (ADT) is the standard treatment for metastatic PCa. However, almost all advanced PCa cases progress to castration-resistant prostate cancer (CRPC) after… CONTINUE READING
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