A TRiP to heart failure.

  title={A TRiP to heart failure.},
  author={R. Vennekens},
  journal={Cardiovascular research},
  volume={99 4},
  • R. Vennekens
  • Published 2013
  • Chemistry, Medicine
  • Cardiovascular research
This editorial refers to ‘Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy’ by Y. Iwata et al ., pp. 757–765, this issue. Transient receptor potential (TRP) channels constitute a somewhat eclectic family of ion channels that share structural similarities and some functional properties, especially cation permeability and weak voltage sensitivity. TRP channels are expressed in virtually every cell type present in the heart, including cardiomyocytes… Expand
1 Citations
Stretch-activated TRPV2 channels: Role in mediating cardiopathies.
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Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy.
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TRPC Channels As Effectors of Cardiac Hypertrophy
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This chapter concentrates on the pivotal role of SR Ca-cycling proteins in health and disease with specific emphasis on their recently reported genetic modifiers. Expand
Timing of Myocardial Trpm7 Deletion During Cardiogenesis Variably Disrupts Adult Ventricular Function, Conduction, and Repolarization
Trpm7 is dispensable in adult ventricular myocardium under basal conditions but is critical for myocardial proliferation during early cardiogenesis, and loss of Trpm7 at an intermediate developmental time point alters theMyocardial transcriptional profile in adulthood, impairing ventricular function, conduction, and repolarization. Expand
A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor–regulated channel
Analysis of the properties of myotubes prepared from δ-sarcoglycan–deficient BIO14.6 hamsters revealed that GRC is activated in response to myocyte stretch and is responsible for enhanced Ca2+ influx and resultant cell damage as measured by creatine phosphokinase efflux, suggesting that G RC is a key player in the pathogenesis of myocyte degeneration caused by dystrophin–glycoprotein complex disruption. Expand
Emerging concepts for the role of TRP channels in the cardiovascular system
The presented results underscore the role of TRP channels in cardiomyocytes, smooth cells and endothelium, and in disease states such as hypertension, cardiac conduction block and cardiac hypertrophy. Expand
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?
Although initially characterized as a noxious heat sensor, TRPV2 now seems to have little to do with temperature sensing but a much more complex physiological profile, and the available information and research progress on the structure, physiology and pharmacology of TRpV2 are reviewed in an attempt to shed some light on the physiological and pharmacological deorphanization. Expand
What do we know about the Transient Receptor Potential Vanilloid 2 ( TRPV 2 ) ion channel ?
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TRPV2 is regulated by insulin and is involved in the autocrine action of this hormone on β-cells, and knockdown of TRPV 2 reduced insulin secretion induced by glucose. Expand