A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders.

@article{Hermosura2005ATV,
  title={A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders.},
  author={Meredith C. Hermosura and Hannah Nayakanti and Maxim V. Dorovkov and Fernanda R. O. Calderon and Alexey G. Ryazanov and David S. Haymer and Ralph M. Garruto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 32},
  pages={11510-5}
}
Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration. There is evidence that TRPM7 is constitutively active… CONTINUE READING

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