A TRPC3 blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), prevents stent-induced arterial remodeling.

Abstract

TRPC-mediated Ca(2+) entry has been implicated in the control of smooth muscle proliferation and might represent a pivotal mechanism underlying in-stent restenosis. As we have observed significant expression of TRPC3 in human smooth muscle from the coronary artery as well as the aorta, we tested the efficiency of a recently discovered TRPC3 selective Ca(2… (More)
DOI: 10.1124/jpet.112.196832

Cite this paper

@article{Koenig2013ATB, title={A TRPC3 blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), prevents stent-induced arterial remodeling.}, author={Sarah Koenig and Michaela Schernthaner and Heinrich Maechler and C Oliver Kappe and Toma N. Glasnov and Gerald Hoefler and Marlen Braune and Eric Wittchow and Klaus Groschner}, journal={The Journal of pharmacology and experimental therapeutics}, year={2013}, volume={344 1}, pages={33-40} }