A TRPC1/TRPC3-mediated increase in store-operated calcium entry is required for differentiation of H19-7 hippocampal neuronal cells.

@article{Wu2004ATI,
  title={A TRPC1/TRPC3-mediated increase in store-operated calcium entry is required for differentiation of H19-7 hippocampal neuronal cells.},
  author={Xiaoyan Wu and Tatiana K. Zagranichnaya and Grzegorz T. Gurda and Eva M. Eves and Mitchel L. Villereal},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 42},
  pages={43392-402}
}
Store-operated calcium entry (SOCE) and TRPC protein expression were investigated in the rat-derived hippocampal H19-7 cell line. Thapsigargin-stimulated Ba2+ entry and the expression of TRPC1, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7 mRNA and protein were observed in proliferating H19-7 cells. When cells were placed under differentiating conditions, a change in TRPC homolog expression profile occurred. The expression of TRPC1 and TRPC3 mRNA and protein dramatically increased, while the expression… CONTINUE READING
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