A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei.

@article{Weiss1992ATC,
  title={A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei.},
  author={Walter R. Weiss and Jay A. Berzofsky and Richard A. Houghten and Martha Sedegah and M Hollindale and Stephen L. Hoffman},
  journal={Journal of immunology},
  year={1992},
  volume={149 6},
  pages={
          2103-9
        }
}
Clone B is a cytotoxic T cell clone induced by immunization with Plasmodium yoelii sporozoites which recognizes an epitope on both the P. yoelii and Plasmodium berghei circumsporozoite proteins. It is CD8, uses the V beta 8.1 TCR, and is Kd restricted. When adoptively transferred, it protects mice against infection by both species of malaria sporozoites, and this protection is dependent on IFN-gamma. Clone B cells are more broadly reactive and protective than previously described murine T cell… CONTINUE READING

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