A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP+M1 in Adults Aged over 50 Years

@inproceedings{Antrobus2012ATC,
  title={A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP+M1 in Adults Aged over 50 Years},
  author={Richard D. Antrobus and Patrick J. Lillie and Tamara K Berthoud and Alexandra J Spencer and James E. McLaren and Kristin Ladell and Teresa Lambe and Anita Milicic and David A. Price and Adrian V S Hill and Sarah C Gilbert},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Current influenza vaccines have reduced immunogenicity and are of uncertain efficacy in older adults. We assessed the safety and immunogenicity of MVA-NP+M1, a viral-vectored influenza vaccine designed to boost memory T cell responses, in a group of older adults. METHODS Thirty volunteers (aged 50-85) received a single intramuscular injection of MVA-NP+M1 at a dose of 1·5×10(8) plaque forming units (pfu). Safety and immunogenicity were assessed over a period of one year. The… CONTINUE READING
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