A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility.

@article{Yoshimura2000ATM,
  title={A T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility.},
  author={Michihiro Yoshimura and Masafumi Nakayama and Yukio Shimasaki and Hisao Ogawa and Kiyotaka Kugiyama and Shota Nakamura and Teruhiko Ito and Yuji Mizuno and Eisaku Harada and Hirofumi Yasue and Yoshihiro Miyamoto and Yoshihiko Saito and Kazuwa Nakao},
  journal={The American journal of cardiology},
  year={2000},
  volume={85 6},
  pages={710-4}
}
In the endothelium, synthesis of nitric oxide (NO) from the amino acid L-arginine is catalyzed by the endothelial NO synthase (eNOS), and the continuously generated NO serves to maintain basal vascular tone. Recently, we discovered a T-786-->C mutation in the 5'-flanking region of the eNOS gene; this mutation reduced the promoter activity of the eNOS gene and was associated with coronary spasm. We examined the vasomotility of the epicardial coronary artery in subjects with and without T-736-->C… CONTINUE READING