A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis

@inproceedings{Lissina2011ASB,
  title={A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis},
  author={Elena Lissina and Brian Patrick Young and Malene L. Urbanus and Xialing Guan and Jonathan D. Lowenson and Shawn Hoon and Anastasia Baryshnikova and Isabelle Riezman and Magali Michaut and Howard Riezman and Leah E Cowen and Markus R. Wenk and Steven G. Clarke and Guri Giaever and Corey Nislow},
  booktitle={PLoS genetics},
  year={2011}
}
Using small molecule probes to understand gene function is an attractive approach that allows functional characterization of genes that are dispensable in standard laboratory conditions and provides insight into the mode of action of these compounds. Using chemogenomic assays we previously identified yeast Crg1, an uncharacterized SAM-dependent methyltransferase, as a novel interactor of the protein phosphatase inhibitor cantharidin. In this study we used a combinatorial approach that exploits… CONTINUE READING

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