A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor

@inproceedings{Sheiner2011ASS,
  title={A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor},
  author={Lilach Sheiner and Jessica L. Demerly and Nicole Poulsen and Wandy L Beatty and Olivier Lucas and Michael S Behnke and Michael W White and Boris Striepen},
  booktitle={PLoS pathogens},
  year={2011}
}
Parasites of the phylum Apicomplexa cause diseases that impact global health and economy. These unicellular eukaryotes possess a relict plastid, the apicoplast, which is an essential organelle and a validated drug target. However, much of its biology remains poorly understood, in particular its elaborate compartmentalization: four membranes defining four different spaces. Only a small number of organellar proteins have been identified in particular few proteins are known for non-luminal… CONTINUE READING

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