A Systematic Review of the Efficacy and Safety of a Fixed-Dose Combination of Umeclidinium and Vilanterol for the Treatment of COPD.

@article{Rodrigo2015ASR,
  title={A Systematic Review of the Efficacy and Safety of a Fixed-Dose Combination of Umeclidinium and Vilanterol for the Treatment of COPD.},
  author={Gustavo J Rodrigo and Hugo E. Neffen},
  journal={Chest},
  year={2015},
  volume={148 2},
  pages={397-407}
}
BACKGROUND COPD guidelines recommend the combined use of inhaled long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) if symptoms are not improved by a single agent. This systematic review tested the hypothesis that the bronchodilator effect of the LABA/LAMA combination, umeclidinium (UMEC)/vilanterol (VIL), would translate into better outcomes without incurring increased adverse events (AEs). METHODS This was a systematic review of randomized, placebo-controlled or… CONTINUE READING
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