A Systematic Review of the Effect of Moderate Intensity Exercise on Function and Disease Progression in Amyotrophic Lateral Sclerosis

@article{Lui2009ASR,
  title={A Systematic Review of the Effect of Moderate Intensity Exercise on Function and Disease Progression in Amyotrophic Lateral Sclerosis},
  author={Andrew Lui and Nancy Byl},
  journal={Journal of Neurologic Physical Therapy},
  year={2009},
  volume={33},
  pages={68-87}
}
  • A. LuiN. Byl
  • Published 1 June 2009
  • Medicine
  • Journal of Neurologic Physical Therapy
Background and Purpose: Amyotrophic lateral sclerosis (ALS) is an idiopathic disease of adults affecting upper and lower motor neurons. In one to four years, progressive weakness, spasticity, and respiratory insufficiency compromise independence and survival. Current medical treatment is limited to medication and supportive care. The benefit and harm of moderate physical exercise are controversial. This review examined current research related to moderate exercise for maintaining independence… 

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AET+UC was not superior to UC alone in preserving HRQoL in ambulatory ALS patient, however, the study was unfortunately underpowered, because only 10 patients completed the protocol.

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Exercise training seems to be safe and feasible in HD patients, however, current knowledge is mainly based on short, small-scale studies and it cannot be transferred to all HD patients so longer-term interventions with larger HD patient cohorts are necessary to draw firm conclusions about the potentially positive effects of exercise training.

Effect of muscle strengthening exercise and time since onset in patients with amyotrophic lateral sclerosis

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