A Systematic Review of Multivitamin–Multimineral Use and Cardiovascular Disease and Cancer Incidence and Total Mortality

  title={A Systematic Review of Multivitamin–Multimineral Use and Cardiovascular Disease and Cancer Incidence and Total Mortality},
  author={Dominik D. Alexander and Douglas L. Weed and Ellen T. Chang and Paige Elizabeth Miller and Muhima A. Mohamed and Laura R. Elkayam},
  journal={Journal of the American College of Nutrition},
  pages={339 - 354}
Multivitamin–multimineral (MVM) supplements are the most frequently used dietary supplements in the United States, with one third or more of the population using at least one daily. However, the health-related implications of MVM use are unclear. Thus, we systematically reviewed and summarized the prospective studies of MVM supplementation and all-cause and cause-specific mortality, as well as cardiovascular disease (CVD) and cancer incidence, to critically evaluate the current evidence on this… 

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Supplement (mis)use in adolescents.

  • K. Tiwari
  • Medicine
    Current opinion in pediatrics
  • 2020
The widespread use of dietary supplements among adolescents, in the background of lack of knowledge and medical guidance, predisposes adolescents to significant health risks, and most healthy adolescents do not need them.

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Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials.

No effect of multivitamin-multimineral treatment on all-cause mortality was observed across all studies, and no statistical evidence of heterogeneity or publication bias was observed.

Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative cohorts.

The Women's Health Initiative study provided convincing evidence that multivitamin use has little or no influence on the risk of common cancers, CVD, or total mortality in postmenopausal women.

Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial.

In this large prevention trial of male physicians, daily multivitamin supplementation modestly but significantly reduced the risk of total cancer.

The Efficacy and Safety of Multivitamin and Mineral Supplement Use To Prevent Cancer and Chronic Disease in Adults: A Systematic Review for a National Institutes of Health State-of-the-Science Conference

A systematic review of the published literature on the efficacy and safety of multivitamin and mineral supplements and certain commonly used single vitamin or mineral supplements in the primary prevention of cancer and chronic disease in the general adult population focused on primary prevention trials in adults.

Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.

Among this population of US male physicians, taking a daily multivitamin did not reduce major cardiovascular events, MI, stroke, and CVD mortality after more than a decade of treatment and follow-up.

Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality.

In cause-specific analyses, use of multivitamins and use of vitamin E were associated with decreased risks of CVD mortality, andMultivitamin and vitamin E use were not associated with cancer mortality.

Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women.

The use of multivitamins was inversely associated with MI, especially long-term use among women with no CVD, especially after 10.2 y of follow-up, according to a prospective, population-based cohort of women from Sweden.

Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality.

Self-selected supplementation with vitamin E, vitamin C, or multivitamin supplements was not associated with a significant decrease in total CVD or CHD mortality and data from ongoing large randomized trials will be necessary to definitely establish small potential benefits of vitamin supplements on subsequent cardiovascular risk.

Multivitamin use and mortality in a large prospective study.

Observational data provide limited support for the hypothesis that multivitamin use in combination with vitamin A, C, or E may reduce heart disease and cardiovascular disease mortality, but add to concerns raised by randomized studies that some vitamin supplements may adversely affect male smokers.

Multivitamin use and the risk of mortality and cancer incidence: the multiethnic cohort study.

There was no clear decrease or increase in mortality from all causes, CVD, or cancer, and risk of morbidity from overall or major cancers among multivitamin supplement users in this cohort.